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pediatrics associates of dallas :: Article Creator Pediatric Diagnostic Associates Will Continue Serving Families As A Practice Independent Of CHI Memorial Pediatric Diagnostic Associates, which was previously associated with CHI Memorial Hospital, announced Thursday it will again become an independent practice under newly formed Scenic City Pediatrics PLLC. Effective Feb. 1, the medical group will enter a new contract with BlueCross BlueShield of Tennessee, including Networks P and S, among other insurers, according to a news release. The change follows a June decision on BlueCross BlueShield of Tennessee's behalf to terminate its contract with Memorial relating to its Network S customers. Managing Partner Dr. Tony Friddell said in a phone interview Pediatric Diagnostic Associates has been under the CHI Memorial umbrella as a managed practice within the hospital system for 28 years. In some shape or form, Pediatric Diagnostic Associates...
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Mining chicken ileal microbiota for immunomodulatory ... - Nature.com

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Abstract

The gut microbiota makes important contributions to host immune system development and resistance to pathogen infections, especially during early life. However, studies addressing the immunomodulatory functions of gut microbial individuals or populations are limited. In this study, we explore the systemic impact of the ileal microbiota on immune cell development and function of chickens and identify the members of the microbiota involved in immune system modulation. We initially used a time-series design with six time points to prove that ileal microbiota at different succession stages is intimately connected to immune cell maturation. Antibiotics perturbed the microbiota succession and negatively affected immune development, whereas early exposure to the ileal commensal microbiota from more mature birds promoted immune cell development and facilitated pathogen elimination after Salmonella Typhimurium infection, illustrating that early colonization of gut microbiota is an important driver of immune development. Five bacterial strains, Blautia coccoides, Bacteroides xylanisolvens, Fournierella sp002159185, Romboutsia lituseburensis, and Megamonas funiformis, which are closely related to the immune system development of broiler chickens, were then screened out and validated for their immunomodulatory properties. Our results provide insight into poultry immune system–microbiota interactions and also establish a foundation for targeted immunological interventions aiming to combat infectious diseases and promote poultry health and production.

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Fig. 1: Overview of experiment design.
Fig. 2: Temporal and spatial development of ileum microbiota in broiler chickens.
Fig. 3: Sequential waves of immune cell expansion after birth.
Fig. 4: Interaction between bacteria and the proportion of immune cells.
Fig. 5: The antibiotic chlortetracycline interferes with the development of ileum microbiota and immune cells.
Fig. 6: Early exposure to ileal commensal microbiota from more mature individuals influences the immune cell composition of chickens.
Fig. 7: Microbiota transplantation enhances the resistance to Salmonella Typhimurium infection of broiler chickens.
Fig. 8: Immunomodulatory properties of five bacterial strains.

Data availability

The raw 16S rRNA gene sequencing data of luminal microbiota from the antibiotic-untreated broiler chickens were obtained from NCBI BioProject PRJNA817429 (unpublished data from our own laboratory), and additional raw 16S rRNA gene sequencing data have been deposited in NCBI BioProject PRJNA904673. The genome data have been deposited in NCBI BioProject PRJNA903494 and PRJNA902159. The transcriptome data have been deposited in NCBI BioProject PRJNA904665. Raw datasets used for multicolor flow cytometry and qRT-PCR are available on FigShare (https://doi.org/10.6084/m9.figshare.21825042).

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