Quadrivalent human papillomavirus (HPV) vaccination was associated with a substantially reduced risk of invasive cervical cancer, according to data published in The New England Journal of Medicine . This study followed an open population of 1,672,983 Swedish girls and women between 10 and 30 years of age until they reached 31 years of age. Of these, 527,871 received at least 1 dose of HPV vaccine during the study period from 2006 through 2017 with 438,939 (83.2%) receiving the vaccine before the age of 17. Cervical cancer was diagnosed in 19 women who had received the vaccine and 538 who did not receive the vaccine. The cumulative incidence in each of these groups was 47 and 94 cases per 100,000 persons, respectively, by 30 years of age. In both the vaccinated and unvaccinated groups, the cumulative incidence of cervical cancer increased rapidly at 23 years of age. For women who received the vaccine before 17 years of age, cumulative incidence was 4 cases per 100,000 persons by th...