Influence of COVID-19 on trust in routine immunization, health information sources and pandemic preparedness in 23 countries in 2023

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pediatrics associates of dallas :: Article Creator Pediatric Diagnostic Associates Will Continue Serving Families As A Practice Independent Of CHI Memorial Pediatric Diagnostic Associates, which was previously associated with CHI Memorial Hospital, announced Thursday it will again become an independent practice under newly formed Scenic City Pediatrics PLLC. Effective Feb. 1, the medical group will enter a new contract with BlueCross BlueShield of Tennessee, including Networks P and S, among other insurers, according to a news release. The change follows a June decision on BlueCross BlueShield of Tennessee's behalf to terminate its contract with Memorial relating to its Network S customers. Managing Partner Dr. Tony Friddell said in a phone interview Pediatric Diagnostic Associates has been under the CHI Memorial umbrella as a managed practice within the hospital system for 28 years. In some shape or form, Pediatric Diagnostic Associates...

Illinois COVID vaccination drive will be a logistical challenge - Crain's Chicago Business

Illinois is gearing up for an unprecedented logistical challenge in the midst of a public health crisis. 

The goal is simple: vaccinate 80 percent of the population against COVID-19. But getting the shots from manufacturers to people’s arms will require precise coordination among numerous public and private entities, as well as an airtight supply chain—not to mention a safe and effective COVID-19 vaccine. 

The complexity, urgency and scope of such a vaccination campaign make this an effort unlike any other in history. 

It will involve a series of hurdles, each uniquely daunting. 

Illinois needs to vaccinate at least 10 million people as quickly as possible—a scale and pace far greater than other vaccination campaigns. 

The state must monitor and enforce compliance with a strict priority regime for the initial rollout, in which health care workers, residents and staff at long-term care and assisted-living facilities, and other essential workers get vaccinated before a general population clamoring for shots. Cold storage and handling requirements add another layer of complexity, with some COVID-19 vaccine candidates stored between minus 76 and minus 112 degrees Fahrenheit, compared with a range of 36 to 46 degrees Fahrenheit for the flu vaccine.

And with many vaccines requiring two doses administered at least three weeks apart, Illinois must track who got which shot when. On top of it all, the state will continue managing COVID-19, which has infected about 400,000 Illinoisans. “All of that together makes for an unprecedented set of challenges for our health care system,” says Katherine Baicker, dean of the University of Chicago Harris School of Public Policy.

A successful vaccination campaign would significantly slow the spread of the virus, allowing normal activities to resume and the economy to recover. Failure would allow the virus and its social and economic consequences to continue unchecked. Illinois recently unveiled a draft of its COVID-19 vaccination plan, as required by the federal government.

At this point, state officials don’t know which vaccines will be distributed, or when they’ll be available. Vaccines from Pfizer and Moderna are expected to have the safety and efficacy data needed to ask the U.S. Food & Drug Administration for emergency use authorization this year. But experts doubt authorization will come before January.

“Vaccination will take place over many months and may unfold in phases, as more vaccine becomes available,” Illinois’ draft plan reads. “Demand for the pandemic vaccine will be high throughout the response.” There are many unknowns and potential bottlenecks that could derail the effort. 

For starters, without an authorized COVID-19 vaccine and details from the federal government around production and distribution, Illinois and Chicago won’t know how many doses they can expect to get during the initial phase of the rollout. Without knowing “what that viable vaccine is going to be, and what manufacturer is going to distribute that first vaccine, it’s really challenging to align a specific process,” says Jeff Thiel, assistant vice president of pharmacy services at NorthShore University HealthSystem.

“There are a lot of hypotheticals,” he says. 

Illinois intends to allocate doses to each public health jurisdiction across the state based on population size, while factoring in hot spots and health equity. For example, if the state gets 200,000 doses, Cook County would get approximately 56,000, or 28 percent, since it’s home to 28 percent of Illinois’ population, the draft plan says.

“Initially, when we anticipate supplies will be limited, the federal government will actually allocate doses to the different states and certain local jurisdictions, so we will not be requesting a number,” says Dr. Candice Robinson, medical director at the Chicago Department of Public Health. “They will just say, ‘You have this many doses.’ ” 

During the first phase, health care workers will get priority, followed by residents and staff at long-term care and assisted-living facilities. The next group in line would be critical workforce members. 

The vaccines will be allocated based on the state’s mapping of priority populations. In its plan, the state says public health departments should coordinate with local health care providers, emergency management and other partners to develop a list of entities serving priority groups and determine whether to set up closed vaccination sites. 

The city says it eventually plans to use large indoor spaces at City Colleges, the largest community college system in Illinois, to vaccinate large numbers of people while maintaining social distancing. 

But before the vaccine can be administered, a complex supply chain orchestration must occur. 

Big questions will need to be addressed: “Do we have the syringes and the vials necessary to deliver these vaccines?” says Tarek Abdallah, an assistant professor of operations at Northwestern University’s Kellogg School of Management. “It becomes about the supporting kits. That’s not trivial, making sure we have those numbers in place.” 

Vaccines and ancillary supplies—such as needles, syringes and alcohol prep pads—will be shipped directly to health care providers. Orders will either come from medical and pharmaceutical supplies company McKesson, the federal government’s main COVID-19 vaccine distributor, or directly from vaccine manufacturers. It will be up to health care providers to procure their own sharps disposal containers, bandages and additional personal protective equipment. 

Making this particular endeavor even more challenging is the fact that storage and handling requirements will vary, with some vaccines needing to be refrigerated or frozen and others requiring ultracold temperatures. 

“Already our supply chains are strained because of COVID, and now we need to use a subset of a subset of our supply chain,” Abdallah says. “It’s a very complicated supply chain, and you need a lot of things to work together for this to happen at a large scale.” 

Ultracold freezers aren’t common outside large health systems and academic medical centers that use them for research purposes. While the city of Chicago does have its own ultracold storage capacity, with the ability to house around 100,000 doses, Robinson says it’ll work closely with health care providers to secure capacity. The CDC has advised jurisdictions against purchasing ultracold storage equipment at this time. 

“Knowing that the first wave of vaccines will be fairly limited, we definitely have the ability to store those on hand,” Thiel says. Still, NorthShore is among health systems looking to buy additional ultracold freezers to expand storage capacity. Many ultralow medical freezers that are about the size of an average refrigerator cost at least $10,000. 

Manufacturers plan to ship vaccines in coolers packed with dry ice. The coolers should be repacked with dry ice within 24 hours of receipt and repacked again within five days, according to the CDC. 

Some of the biggest uncertainties include how to supply rural areas that don’t expect to vaccinate thousands of people at a time, and what to do if people don’t show up. 

“Let’s say we build the supply chain and people don’t buy in—they don’t want to take the vaccine or they don’t trust the vaccine that’s being delivered,” Abdallah says. “It’s incredibly important in terms of efficiencies to the supply chain to limit the amount of vaccines that get disposed.” 

Beyond a possible supply shortages and missing links in the cold chain, industry observers say bad weather could stall the vaccine rollout if shipments don’t get to providers within the optimal timeframe. 

In the case of a transportation or security issue, the state says it’s prepared to call on the Illinois Department of Corrections, which maintains refrigerated fleet vehicles to transport biologics, and the Illinois National Guard, as well as the Illinois Trucking Association. 

With some vaccines requiring two doses roughly three weeks apart, timing will be crucial. 

“For most vaccines, an increase in time between doses doesn’t mean you have to start the series over,” Robinson says. “However, we don’t know what that will be for COVID yet. We have to wait until the vaccines are approved and we receive further guidance from CDC on that.” 

Providers in the state will use the existing Illinois Comprehensive Automated Immunization Registry Exchange, or I-CARE, to order vaccines and track administration, ensuring that each individual gets two doses of the same vaccine. 

Thiel compares some aspects of the vaccine rollout to the handling of remdesivir. The antiviral drug, which has been used to treat patients hospitalized with COVID-19, faced shortages in the spring before drugmaker Gilead bumped up production. Early on, remdesivir was shipped in one of two formulations—a powder that providers reconstituted with saline and stored at room temperature or a refrigerated liquid version, Thiel says. “Oftentimes we didn’t know which was coming until it actually arrived at the hospital.” 

As for the role of retail pharmacies, the Trump administration recently announced agreements with Walgreens and CVS to administer COVID-19 vaccines at long-term care facilities nationwide. A representative for Deerfield-based Walgreens did not respond to a question about the pharmacy chain’s capacity to administer COVID-19 vaccines in stores. 
For now, the city and state are working closely with local health care providers, including hospitals and pharmacies, to flesh out their vaccination campaigns and prepare for the challenge ahead. 

“It’s a large undertaking to get 80 percent of the almost 3 million people who live in Chicago vaccinated,” Robinson says. “It’s going to take all the planning from the city, close coordination from all levels of government and our partners, and utilizing all our resources to make it happen.”  



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