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immunizations for older adults :: Article Creator Shingles And RSV Vaccines Linked To Lower Dementia Risk In Older Adults: Study UK: Researchers at the University of Oxford have found in a new study that older U.S. Adults who received AS01-adjuvanted vaccines—either for shingles or respiratory syncytial virus (RSV)—were less likely to be diagnosed with dementia within 18 months. Since both vaccines showed comparable results, the study points to the AS01 adjuvant as a potential contributor to the protective effect against dementia. Published in npj Vaccines, the large-scale study assessed over 430,000 individuals using electronic health record (EHR) data from the U.S.-based TriNetX network. It compared those who received AS01-based shingles (Shingrix) or RSV (Arexvy) vaccines with individuals who received flu vaccines but not the AS01-adjuvanted shots. The findings were as follows: Individuals who received either the AS01 shingles or ...

New Study Suggests Separating Rotavirus & Oral Poliovirus Vaccinations - Vax Before Travel

A new study’s findings suggest that oral poliovirus vaccine (OPV) given concomitantly with rotavirus vaccine Rotarix was a substantial contributor to reduced antirotavirus IgA seroconversion.

This is an important finding published on December 30, 2019, since rotavirus vaccination is the primary method for preventing rotavirus infections and reducing the severity of rotavirus gastroenteritis among young children globally.

Despite the success of rotavirus vaccines over the last decade, rotavirus remains a leading cause of severe diarrheal disease among young children. Since the pivotal clinical trial results were released in 2006, rotavirus vaccines have been integrated into the national immunization programs of approximately 96 countries.

Further progress in reducing the burden of disease is inhibited, in part, by vaccine underperformance in certain settings. 

Early clinical trials suggested that oral poliovirus vaccine, when administered concomitantly with rotavirus vaccine, reduces rotavirus seroconversion rates after the 1st rotavirus dose with modest or nonsignificant interference after completion of the full rotavirus vaccine course. 

This study pooled individual-level data from GlaxoSmithKline’s Phase II and III clinical trials of the monovalent rotavirus vaccine (RV1), Rotarix, including 7,280 vaccinated infants (5–17 weeks of age at first vaccine dose) from 22 trials and 33 countries/territories.

Rotarix is a live, attenuated rotavirus vaccine derived from the human 89-12 strain which belongs to G1P type. 

The researchers examined the relationship between individual- and country-level predictors and immune response to RV1 vaccination measured via serum antirotavirus immunoglobulin A (IgA) seroconversion and serum antirotavirus IgA titer.

This study’s findings suggest that OPV given concomitantly with RV1 was a substantial contributor to reduced antirotavirus IgA seroconversion, and this interference was apparent after the 2nd vaccine dose of RV1.

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Moreover, this study highlights the importance of concomitant OPV and RV1 administration and provides encouraging evidence to suggest that the eventual withdrawal of OPV from national immunization programs could improve rotavirus vaccine performance.

Currently, there are 4 live attenuated, oral rotavirus vaccines administered during infancy have received World Health Organization prequalification: 

  • GlaxoSmithKline’s (GSK) monovalent rotavirus vaccine (Rotarix, “RV1”)
  • Merck’s pentavalent vaccine (RotaTeq)
  • Serum Institute of India’s pentavalent vaccine (Rotasiil)
  • Bharat Biotech’s monovalent vaccine (Rotavac)

The introduction of these vaccines has led to dramatic reductions in rotavirus disease in many settings.

Polio can be prevented with a vaccine. Inactivated polio vaccine (IPV) is the only polio vaccine that has been given in the United States since 2000. The IPV is given by a shot in the arm or leg, depending on the person’s age.

The OPV is used in other countries.

This study funding:  JMB received financial support to conduct this research from the Laney Graduate School of Emory University. BAL’s work was supported by NIH grants R01AI112970 and R01GM124280 and the Modeling the Impact of Rotavirus Vaccination in GAVI Countries project supported by Imperial College London. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

These researchers disclosed industry relationships.

Rotavirus Vaccine news published by Vax-Before-Travel



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