Screening and Testing for Hepatitis B Virus Infection ...

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arthritis osteoporosis and rheumatology associates :: Article Creator Arthritis & Rheumatology Clinic Contact Information Arthritis & Rheumatology Clinic 740 Jordan Street, Shreveport, LA 71101 Office: (318) 424-9240 Fax: (318) 424-0022 www.Arthdoc.Com Find us on Facebook About Dr. Goodman Robert E. Goodman, M.D. Board-Certified Rheumatologist "Blending the most innovative approaches in rheumatology and arthritis treatments with personalized patient care" Board Certified Rheumatologist Robert E. Goodman, M.D., of the Arthritis and Rheumatology Clinic in Shreveport, has been caring for patients in the Ark-La-Tex since 1985. Dr. Goodman combines his specialized training and experience with personalized care to provide patients with leading-edge technology and the latest treatment options. Dr. Goodman and the Arthritis & Rheumatology Clinic Healthcare Team of caring, compassionate healthcare professiona...
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Experimental TB vaccine a ‘game changer’ that offers new hope - Business Day

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The Bacille Calmette Guérin (BCG) vaccine, routinely given to babies around the world, was developed more than 90 years ago, and provides limited protection that wanes by adolescence. GSK’s candidate vaccine M72/AS01E was tested in 3,300 HIV negative adults in Kenya, SA and Zambia who had latent TB, and the results of the phase 2b trial were published in the New England Journal of Medicine this week.  

Participants were either given two doses of the vaccine or a placebo, and followed for three years to see if they developed pulmonary TB. Only 13 people who received the shots got TB, compared to 26 who did not.

“The trial is a game changer because it is the first time a TB vaccine candidate has been shown to offer protection to people who are already infected with the Mycobacterium tuberculosis bacillus. Those people, about two thirds of SA adults, are at risk of progression to TB disease,” said the study’s principal investigator Mark Hatherill, director of the SA Tuberculosis Vaccine Initiative.

GSK’s experimental vaccine contains TB proteins that trigger an immune response, but the mechanism is not yet fully understood, said Hatherill.

Further research was needed to determine whether the vaccine protected people who had not yet been infected with TB and those living with HIV, and to determine whether the protection was durable. Ideally a vaccine should confer protection for at least 10 years, he said.

“These questions must be asked and answered in a bigger confirmatory trial or trials, which will need a funding commitment from government and non-governmental stakeholders worldwide. These answers will be critical in getting the vaccine to a broad market,” he said.

In a separate development, French pharmaceutical manufacturer Sanofi announced on Thursday that it had slashed the price of its TB antibiotic rifapentine by two thirds, to a net ex-factory price of $15 for eligible countries in low and middle-income countries, including SA.



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