These Are the Top Pediatric Care Providers in Westchester

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immunizations for older adults :: Article Creator Shingles And RSV Vaccines Linked To Lower Dementia Risk In Older Adults: Study UK: Researchers at the University of Oxford have found in a new study that older U.S. Adults who received AS01-adjuvanted vaccines—either for shingles or respiratory syncytial virus (RSV)—were less likely to be diagnosed with dementia within 18 months. Since both vaccines showed comparable results, the study points to the AS01 adjuvant as a potential contributor to the protective effect against dementia. Published in npj Vaccines, the large-scale study assessed over 430,000 individuals using electronic health record (EHR) data from the U.S.-based TriNetX network. It compared those who received AS01-based shingles (Shingrix) or RSV (Arexvy) vaccines with individuals who received flu vaccines but not the AS01-adjuvanted shots. The findings were as follows: Individuals who received either the AS01 shingles or ...
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Experimental TB vaccine a ‘game changer’ that offers new hope - Business Day

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The Bacille Calmette Guérin (BCG) vaccine, routinely given to babies around the world, was developed more than 90 years ago, and provides limited protection that wanes by adolescence. GSK’s candidate vaccine M72/AS01E was tested in 3,300 HIV negative adults in Kenya, SA and Zambia who had latent TB, and the results of the phase 2b trial were published in the New England Journal of Medicine this week.  

Participants were either given two doses of the vaccine or a placebo, and followed for three years to see if they developed pulmonary TB. Only 13 people who received the shots got TB, compared to 26 who did not.

“The trial is a game changer because it is the first time a TB vaccine candidate has been shown to offer protection to people who are already infected with the Mycobacterium tuberculosis bacillus. Those people, about two thirds of SA adults, are at risk of progression to TB disease,” said the study’s principal investigator Mark Hatherill, director of the SA Tuberculosis Vaccine Initiative.

GSK’s experimental vaccine contains TB proteins that trigger an immune response, but the mechanism is not yet fully understood, said Hatherill.

Further research was needed to determine whether the vaccine protected people who had not yet been infected with TB and those living with HIV, and to determine whether the protection was durable. Ideally a vaccine should confer protection for at least 10 years, he said.

“These questions must be asked and answered in a bigger confirmatory trial or trials, which will need a funding commitment from government and non-governmental stakeholders worldwide. These answers will be critical in getting the vaccine to a broad market,” he said.

In a separate development, French pharmaceutical manufacturer Sanofi announced on Thursday that it had slashed the price of its TB antibiotic rifapentine by two thirds, to a net ex-factory price of $15 for eligible countries in low and middle-income countries, including SA.



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