Influence of COVID-19 on trust in routine immunization, health information sources and pandemic preparedness in 23 countries in 2023

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pediatrics associates of dallas :: Article Creator Pediatric Diagnostic Associates Will Continue Serving Families As A Practice Independent Of CHI Memorial Pediatric Diagnostic Associates, which was previously associated with CHI Memorial Hospital, announced Thursday it will again become an independent practice under newly formed Scenic City Pediatrics PLLC. Effective Feb. 1, the medical group will enter a new contract with BlueCross BlueShield of Tennessee, including Networks P and S, among other insurers, according to a news release. The change follows a June decision on BlueCross BlueShield of Tennessee's behalf to terminate its contract with Memorial relating to its Network S customers. Managing Partner Dr. Tony Friddell said in a phone interview Pediatric Diagnostic Associates has been under the CHI Memorial umbrella as a managed practice within the hospital system for 28 years. In some shape or form, Pediatric Diagnostic Associates...
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Priming the body's immune system with personalized cancer vaccines - Genetic Literacy Project

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In 2014, at Washington University School of Medicine in St. Louis, six melanoma patients received infusions of an anticancer vaccine composed of their own dendritic cells. Our WashU colleagues had extracted immune cells from the patients’ blood two months earlier, cultured them in the lab, and mixed in peptides selected and synthesized based on specific mutations present in the genomes of each patient’s tumor…

This first test of personalized cancer vaccines in people grew out of our collaborative efforts to develop a computational pipeline to identify tumor-unique mutations that could induce immune responses in cancer patients, helping them to fight their diseases. … In contrast to cell-based immune therapies, which directly provide the patient with tumor-attacking T cells, the idea was that these neoantigens could be used to create vaccines that stimulate the differentiation of endogenous killer T cells.

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These results indicated that it was possible to prime the immune system to recognize nonself, cancer-specific peptides and to elicit an antitumor T cell response that targets cancer cells.

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Since the publication of our personalized melanoma vaccine trial, three subsequent studies have demonstrated the potential of neoantigen-based vaccines in treating human cancers. Both academic and industry sponsors are now conducting many more such clinical trials.

Read full, original post: Personalized Cancer Vaccines in Clinical Trials



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