Influence of COVID-19 on trust in routine immunization, health information sources and pandemic preparedness in 23 countries in 2023

Image
pediatrics associates of dallas :: Article Creator Pediatric Diagnostic Associates Will Continue Serving Families As A Practice Independent Of CHI Memorial Pediatric Diagnostic Associates, which was previously associated with CHI Memorial Hospital, announced Thursday it will again become an independent practice under newly formed Scenic City Pediatrics PLLC. Effective Feb. 1, the medical group will enter a new contract with BlueCross BlueShield of Tennessee, including Networks P and S, among other insurers, according to a news release. The change follows a June decision on BlueCross BlueShield of Tennessee's behalf to terminate its contract with Memorial relating to its Network S customers. Managing Partner Dr. Tony Friddell said in a phone interview Pediatric Diagnostic Associates has been under the CHI Memorial umbrella as a managed practice within the hospital system for 28 years. In some shape or form, Pediatric Diagnostic Associates...

HPV vaccination substantially reduces risk for invasive cervical cancer - Healio

September 30, 2020

2 min read

Source/Disclosures

Disclosures: Lei and Sparén report no relevant financial disclosures. Please see the study for all other authors’ relevant financial disclosures.

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.

Quadrivalent HPV vaccination substantially reduced the risk for invasive cervical cancer among Swedish girls and women aged 10 to 30 years, according to results of a study published in The New England Journal of Medicine.

“This is the first time that we, on a population level, are able to show that HPV vaccination is protective not only against cellular changes that can be precursors to cervical cancer, but also against actual invasive cervical cancer,” Jiayao Lei, PhD, researcher in the department of medical epidemiology and biostatistics at Karolinska Institutet in Sweden, said in a press release. “It is something we have long suspected but that we are now able to show in a large national study linking HPV vaccination and development of cervical cancer at the individual level.”

Quadrivalent HPV vaccination substantially reduced the risk for invasive cervical cancer among Swedish girls and women aged 10 to 30 years.
Quadrivalent HPV vaccination substantially reduced the risk for invasive cervical cancer among Swedish girls and women aged 10 to 30 years.

Previous studies have shown the effectiveness of the quadrivalent HPV vaccine, which covers HPV types 6, 11, 16 and 18, in preventing high-grade cervical lesions. There is a lack of data, however, on the relationship between vaccination and subsequent risk for invasive cervical cancer.

Jiayao Lei, PhD

Jiayao Lei

Lei and colleagues assessed this association using data from Swedish demographic and health registries of 1,672,983 girls and women aged 10 to 30 years. Researchers followed the study population from 2006 to 2017, during which nearly one-third of the girls and women (n = 527,871) received at least one dose of the quadrivalent HPV vaccine, most before age 17 years.

The investigators controlled the analyses for age at follow-up, calendar year, county of residence and parental characteristics, including education, household income, mother’s country of birth and maternal disease history.

Results showed 19 of those who received the vaccine and 538 of those who did not were diagnosed with cervical cancer, for a cumulative incidence of 47 cases per 100,000 persons among the vaccinated group and 94 cases per 100,000 persons among the unvaccinated group.

Comparison of the vaccinated and unvaccinated groups showed an incidence rate ratio (IRR) of 0.51 (95% CI, 0.32-0.82) after adjusting for age at follow-up. After adjusting for calendar year, residential and parental characteristics, researchers observed an IRR of 0.37 (95% CI, 0.21-0.57).

Stratification according to age at the start of vaccination showed fully adjusted IRRs for cervical cancer of 0.12 (95% CI, 0-0.34) among girls vaccinated before age 17 years, 0.47 (95% CI, 0.27-0.75) among women vaccinated between ages 17 and 30 years, 0.36 (95% CI, 0.18-0.61) among those vaccinated before age 20 years and 0.38 (95% CI, 0.12-0.72) among those vaccinated between ages 20 and 30 years.

Pär Sparén, MD

Pär Sparén

“Girls vaccinated at a young age seem to be more protected, probably because they are less likely to have been exposed to HPV infection given that the vaccine has no therapeutic effect against a preexisting condition,” Pär Sparén, MD, professor in the department of medical epidemiology and biostatistics at Karolinska Institutet, said in the press release. “Our data strongly support continuing HPV vaccinations of children and adolescents through national vaccination programs.”



Comments

Popular posts from this blog

These Are the Top Doctors in the Hudson Valley in 2022

William Buoni, MD - Wexner Medical Center

Who are the top doctors in Columbus? Search by specialty with Columbus Monthly's 2021 list