Screening and Testing for Hepatitis B Virus Infection ...

Image
arthritis osteoporosis and rheumatology associates :: Article Creator Arthritis & Rheumatology Clinic Contact Information Arthritis & Rheumatology Clinic 740 Jordan Street, Shreveport, LA 71101 Office: (318) 424-9240 Fax: (318) 424-0022 www.Arthdoc.Com Find us on Facebook About Dr. Goodman Robert E. Goodman, M.D. Board-Certified Rheumatologist "Blending the most innovative approaches in rheumatology and arthritis treatments with personalized patient care" Board Certified Rheumatologist Robert E. Goodman, M.D., of the Arthritis and Rheumatology Clinic in Shreveport, has been caring for patients in the Ark-La-Tex since 1985. Dr. Goodman combines his specialized training and experience with personalized care to provide patients with leading-edge technology and the latest treatment options. Dr. Goodman and the Arthritis & Rheumatology Clinic Healthcare Team of caring, compassionate healthcare professiona...

A Pioneering Precision Medicine Cancer Vaccine for Canines - Technology Networks

In a first-of-its-kind study, scientists at the University of Missouri have helped advance a patient-specific, precision medicine treatment for bone cancer in dogs. By creating a vaccine from a dog’s own tumor, scientists worked with ELIAS Animal Health to target specific cancer cells and avoid the toxic side effects of chemotherapy, while also opening the door for future human clinical trials.

Osteosarcoma, or bone cancer, is not common in humans, representing only about 800-900 new cases each year in the U.S. About half of those cases are reported in children and teens. However, for dogs this disease is much more common, with more than 10,000 cases a year occurring in the U.S.

“A vaccine is made out of the dog’s own tumor for the dog’s immune system to recognize,” said Jeffrey Bryan, a professor of oncology at the MU College of Veterinary Medicine and director of Comparative Oncology Radiobiology and Epigenetics Laboratory. “The dogs received no chemotherapy and received only immunotherapy after their surgery. It’s the first time that dogs with osteosarcoma have experienced prolonged survival without receiving chemotherapy, which is really exciting.”

In the study, researchers partnered with ELIAS Animal Health to test a vaccine to treat osteosarcoma by using a dog’s own lymphocytes. Overall, the dogs receiving this therapy had more than 400 days of remission compared to about 270 days for dogs receiving chemotherapy in a separate study by the National Cancer Institute.

“Lymphocytes are immune cells that recognize where pathogens are hiding in the body and then kill the cells harboring those pathogens,” Bryan said. “After we remove the tumor, we create a vaccine using the dog’s tumor cells to stimulate anti-tumor lymphocytes. These lymphocytes are then collected by apheresis and expanded outside the body by Elias Animal Health to create a transfusion of the patient’s immune cells. These cells are activated and essentially really angry at whatever they are supposed to attack. When put back into the body, they should identify and destroy tumor cells. Ideally, this immune response would destroy every last tumor cell.”

Mizzou researchers hope to continue immunotherapy discovery with dogs in order to optimize the new therapy for future human clinical trials with the hopes of treating osteosarcoma and other cancers, especially metastatic osteosarcoma in children. They are currently continuing this work through another immunotherapy trial in progress with a grant by the Morris Animal Foundation through the National Cancer Institute Comparative Oncology Trials Consortium.

Brian Flesner, an assistant professor of oncology at the MU College of Veterinary Medicine, presented this research at the 2018 Veterinary Cancer Society Annual Conference in Louisville, Kentucky. The same data was shared at the 2018 Paws 4 a Cure Conference in Boston by Jeffrey Bryan.

This article has been republished from materials provided by the University of Missouri. Note: material may have been edited for length and content. For further information, please contact the cited source.



http://bit.ly/2Wye6ex

Comments

Popular posts from this blog

These Are the Top Doctors in the Hudson Valley in 2022

William Buoni, MD - Wexner Medical Center

Who are the top doctors in Columbus? Search by specialty with Columbus Monthly's 2021 list